@article{Suwitono_Kartasasmita_Pamudji_Ibrahim_2019, title={Kinetic Analysis on Decomposition of Pentaerythrityl Tetranitrate under Influence of Thiols}, volume={7}, url={https://jurnal.unai.edu/index.php/isc/article/view/1993}, DOI={10.35974/isc.v7i1.1993}, abstractNote={<p>Pentaerythrityl tetranitrate (PETN) is an organic nitrate compound used in the therapy as<br>general vasodilator in the treatment of angina pectoris. PETN acts as prodrug for nitric oxide<br>as active component. However, in clinical association, it is known a decreased ability of<br>organic nitrate to do chemical reduction, which is metabolic tolerance, by upregulation in<br>endogenic thiol system. It has been proved that supplementation of thiol is able to overcome<br>tolerance to nitrate, nevertheless there is no comprehensive reports on interaction between<br>organic nitrate and thiol compounds. The goal of this research is to study decomposition<br>reaction kinetic of PETN under influence N-acetyl cysteine (NAC) and thiosalicylic acid<br>(TSA) as thiol compounds, in the physiological condition. PETN as tracing compound were<br>monitored by chromatographic system, with ratio of thiols used was equal, doubled, five<br>times, and ten times folds. Data were analyzed kinetically by using math equation for reaction<br>order 1, 2, and composite order 1 (equivalence). The result showed the linearity values on<br>kinetic derivative, where correlation coefficient, r, is higher than 0.9 (r ≥ 0.9) for composite<br>order 1. The result will give scientific contribution about tolerance phenomena in organic<br>nitrate, particularly in the role of thiol compound to overcome nitrate tolerance.</p>}, number={1}, journal={Abstract Proceedings International Scholars Conference}, author={Suwitono, Marvel Reuben and Kartasasmita, R.E and Pamudji, J.S and Ibrahim, S.}, year={2019}, month={Dec.}, pages={1901-1907} }