Hypoglycemic Activity of Okra (Abelmoschus esculentus) in Participants with Impaired Fasting Glucose
AbstractImpaired fasting glucose (IFG) is characterized by a blood glucose level higher than normalbut lower than that of diabetes level. Abelmoschus esculentus (okra) is an alternativehypoglycemic and antidiabetic plant due to its phytochemical constituents that regulateintestinal glucose absorption and prevents insulin resistance. This study determined thehypoglycemic activity of okra among IFG participants. Subjects were random subjects withimpaired fasting glucose results upon screening. Quasi-experimental pre-test post-test wasused where a standard glucose load was consumed in the control phase and powdered okraseed-peel mixed with the glucose load was consumed during the experimental phase. The bloodsugar concentration was measured again every hour until three hours after consumption of thestandard glucose load. In the experimental phase, the same group of participants was asked toconsume 75 grams of glucose load with powdered okra peel that depends on their body weight(200 mg/kg of body mass). Fasting, 1 -hour, 2-hour and 3-hour glucose concentration weremeasured the same way it was done during the control phase. Statistical analysis revealed thatAbelmoschus esculentus has its hypoglycemic effect only during the first hour while dataresults for the 2nd and 3 rd hour are considered insignificant. The results proved that okra’smechanism in lowering glucose levels is immediate yet of short duration. Based on the datagathered, the researchers conclude that the powdered peel of Abelmoschus esculentus (okra) iseffective in lowering the blood glucose levels of IFG individuals only during the first hour afterthe administration of oral glucose load. Abelmoschus esculentus may not be effective inlowering the blood glucose after the next hours due to the fact that its mechanism of action isimmediate but of short duration. The researchers recommend future researches on the study ofAbelmoschus esculentus using increased dosage of each participant and that the experimentshould be performed at the same month.
Banu, S., Jabir, NR …. Manjunath, NC,. (2015). Reduction of post-prandial hyperglycemia by mulberry tea in type-2 diabetes patients. Saudi Journal of Biological Sciences.22(1):3236. doi:10.1016/j.sjbs.2014.04.005.
Bauman, H., & Porter, A. Food as medicine: okra (Abelmoschus esculentus, Malvaceae). American Botanical Council. HerbalEGram: Volume 12, Issue 8, August 2015. http://cms.herbalgram.org/heg/volume12/08August/FoodAsMedicineOkra.html?ts=1443692451&signature=48785cecf469c11f8e5c981837878fd5&ts =1531649829&signature=25c56c8cb84d900ef2b139d88fdd7499. Accessed July 15, 2018.
Chung, K. T. (1998 Aug). Tannins and human health: a review. Crit Rev Food Sci Nutr. 38(6):421-64.
Fan, S., Guo, L., Zhang, Y., Sun, Q., Yang, B., & Huang, C. Okra polysaccharide improves metabolic disorders in high-fat diet-induced obese C57BL/6 mice. Mol Nutr Food Res.2013;57:2075https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.201300054. Accessed June 28, 2018
Firdous, S. M. (2014). Phytochemicals for treatment of diabetes. EXCLI Journal. 13:451-453.
Hajera, K., Ajijur, R., Mohitosh, B., & Anwar, UI. Water-soluble fraction of abelmoschus esculentus L Interacts with glucose and metformin hydrochloride and alters their absorption kinetics after coadministration in rats ISRN Pharm.; 260537. doi: 10.5402/2011/260537.
Kwon, O., Eck, P., & Chen, S. et al. Inhibition of the intestinal glucose transporter GLUT2 by flavonoids FASEB J., 21 (2007), pp. 366-377 https:// doi.org/10.1016/j.fshw.2012.08.002
Lee, M. S., & Phuong, T. T. (2015). Stimulation of glucose uptake by triterpenoids from Weigela subsessilis. Phytother. Res 2010,24,49-53. Phytochem Rev. 14(4): 675-690. doi: 10.1007/s11101 -014-9369-x.
Nazaruk, J., Borzym-Kluczyk, M. (2015). The role of triterpenes in the management of diabetes mellitus and its complications. Phytochemistry Reviews. 14(4):675- 690. doi:10.1007/s11101-014-9369-x.
Nazaruk, J., & Borzym-Kluczyk, M. (2014). The role of triterpenes in the management of diabetes mellitus and its complications. Phytochem Rev. 14(4):675- 690.doi.10.1007/s11101 -014-9369-x.
Nazira, M., Qamar, S., Ahmed, U. et al.(2017). Antioxidant and antidiabetic effects of flavonoids: A structure-activity relationship based study. BioMed Research International, vol. 2017, Article ID 8386065, 14 pages. https:// doi.org/10.1155/2017/8386065.
Neetu, M., Dileep, K., & Rizvi, SI. (2016). Protective effect of Abelmoschus esculentus against alloxan-induced diabetes in wistar strain rats, Journal of Dietary Supplements. 13:6, 634-646, DOI: 10.3109/19390211.2016.1164787.
Panche, A. N., Diwan, A. D., & Chandra, S. R. (2016). Flavonoids: an overview. Journal of Nutritional Science. 5:e47. doi:10.1017/jns.2016.41.
Prabune, A., Sharma, S., & Ojha, B. (2017). Abelmoschus esculentus potential natural compound for prevention and management of diabetes and diabetic inducedhyperglycemia. International Journal of Herbal Medicine. 5(2):65-68. https://www. researchgate.net/ publication/ 322819860. Accessed June 29, 2018.
Ramachandran, S., Sandeep, V. S., Srinivas, N. K., & Dhanaraju, M. D. (2010) Anti-diabetic activity of abelmoschus esculentus linn on alloxan-induced diabetic rats. Research & Reviews in BioSciences, 4. 15
Sabitha, V., Ramachandran, S., & Naveen, KR. (2011). Panneerselvam K. Antidiabetic and antihyperlipidemic potential of Abelmoschus esculentus (L.) Moench. in streptozotocin-induced diabetic rats. Journal of Pharmacy and Bioallied Sciences, 3(3):397-402. doi:10.4103/0975-7406.84447.
Saritha, M. (2017). Flavonoids The most potent poly-phenols as antidiabetic agents: an overview. Mod Appro Drug Des, 1(3). MADD.000513.
Worede, A., Alemu, S., Gelaw, Y. A., Abebe, M. (2017). The prevalence of impaired fasting glucose and undiagnosed diabetes melittus and associated risk factors among adults living in a rural Koladiba town, northwest Ethiopia. BMC Res, 10(1):251.Published 2017 Jul 6.doi: 10.1186/s13104-017-2571-3.
Copyright (c) 2019 Abstract Proceedings International Scholars Conference
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Copyright © 2019 ISC Committee.