MUTAGENICITY OF AMORPHOPHALLUS PAEONIIFOLIUS CORM AQUEOUS EXTRACTS USING ALLIUM TOXICITY ASSAY

Authors

  • Joanna Nicole G. Baniqued Adventist University of The Philippines
  • Orlex B. Yllano Adventist University of The Philippines

https://doi.org/10.35974/isc.v4i1.1869

Keywords:

Lethal Dose (LD₅₀), Allium Toxicity Assay, Mutagenicity, Chromosomal aberrations, Mitotic index

Abstract

Amorphophallus  paeoniifolius or Elephant Foot yam is widely used in folk medicine for acute rheumatism, tumors, lung swelling, asthma, vomiting, and abdominal pain. Even though this plant is currently utilized as herbal medicine in some parts of the world, its toxicity studies are not yet established.  This study investigated the toxicity of A. paeoniifolius corm extracts to Allium cepa chromosomes. Results showed that as the corm concentration increases, the number of root germination of the A. cepa decreases [control (4.33), 2% (2.67),

4% (2.33), and 8% (1.00). Interestingly, the mitotic index also decreased – control (34.61%), 2% (20.75%), and 4% (11.08%), while the chromosomal aberrations increased – control (12.03%), 2% (21.08%), and 4% (59.68%). Prominent chromosomal aberrations that were observed in treated samples were laggards, vagrant chromosomes, bridge with fragments, sticky chromosomes, disoriented chromosomes and chromosomal breakage. To our knowledge,  this is the first evidence of the mutagenicity and root growth inhibition of A. paeoniifolius corm extracts to A. cepa.

 

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Published

2016-10-25

How to Cite

Baniqued, J. N. G., & Yllano, O. B. (2016). MUTAGENICITY OF AMORPHOPHALLUS PAEONIIFOLIUS CORM AQUEOUS EXTRACTS USING ALLIUM TOXICITY ASSAY. 11th International Scholars Conference, 4(1), 78. https://doi.org/10.35974/isc.v4i1.1869

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