The Effectiveness of Cherry LeavesDecoction (Muntingia Calabura L) Towards SGOT SGPT Serum on Male Wistar Rats in Critical Hepatitis Model

Abstract

Critical Hepatitisis is caused by viruses, alchol and drugs which are characterized by the
increasing values of SGOT SGPT. The aim of this study is to determine the effectiveness of
decoction extracts of cherry leaves (Muntingia Calabura L) towards serum SGOT SGPT on
male wistar rats in critical hepatitis model. The rats that have been used are in number of 30
male rats with the weight is 180-200 grams and the age of 2-3 months devide into 3
groups,which are negative groups, positive groups and treatment groups.Each groups consist
of 10 rats. The negative group is given an usual food and drink. The positive group and the
treatment group are induced with 120 mg/ oral paracetamol for 7 days to increase serum levels
of SGOT SGPT. The treatment group is given a decoction therapy of 10 grams cherry leaves
in 100cc of water that is given 3.6cc/oral for 7 days.While the positive group is only given a
regular food and drink for 7 days.ANOVA test is conducted to analyze this studyby using SPSS
24 version. It is found in the result of the study that there are significant differences in serum
level of SGOT between the treatment group, positive group and negative group (p<0,05). There
is a significant value difference of SGPT in the treatment group and the positive group
(p<0,05). However, there is no significant difference between the level of SGPT in the
treatment group and the negative group (p=0,121).The conclusion is cherry leaves decoction
(Muntingia Calabura L) has an effect towards the decrease of SGOT SGPT serum level on
male wistar rats in critical hepatitis model.