Effectiveness Rosy Periwinkle (Catharanthus roseus L.) Decoction Toward Urea and Creatinine Serum Levels of Male Wistar Strain Rats with Acute Kidney Failure Model

Abstract

Acute kidney failure is a disorder that occurs suddenly in the ability of the kidneys to
infiltrate blood, which is characterized by increased levels of urea and creatinine within a few
hours or days. This study aims to determine the effectiveness of the Rosy Periwinkle (
Catharanthus roseus L. ) on the levels of urea and creatinine in male Wistar Strain with acute
kidney failure models. The object of the study were30 male Wistar Strain Rats aged 2-3
months with a weight of 180-200 grams per rat. The study was divided into three groups,
namely the treatment group, positive control group, and negative control group. Each group
consists of 10 male rats. Tread leaves taken as much as 5.2 grams are boiled in 300 cc of
water until the remaining 100 cc of boiled water. The treatment group and positive control
group induced gentamicin 12 mg in 0.3 cc intraperitoneal / rat / day for 7 days. The treatment
group was given boiled water for as much as 3.6 cc / day orally for 7 days. Giving a
gentamicin injection to damage the kidneys. Data collection on urea and creatinine levels was
calculated using the SPSS program version 24 One Way ANOVA test to compare creatinine
urea levels. The results showed that there were significant differences in creatinine urea
levels between the treatment group and the positive control group (p <0.05). The conclusion
of this study is that the boiled water of Rosy Periwinkle ( Catharanthus roseus L. ) is effective
in reducing the level of urea and creatinine of male Wistar Strain Rats with acute kidney
failure models