Effectiveness of Boiled Figs Leaf (Ficus Carica L) Towards Ureum and Creatinin Serum of Male Wistar Strain Rats with Acute Renal Failure Model

Abstract

Acute renal failure is a set of clinical symptoms characterized by increased levels of
creatinine and blood urea nitrogen and a rapids decrease in the rate of glomerular filtration.
The Objectives of this study was to determine the effectiveness of brewed tin water (Ficus
Carica L) against urea and creatinine serum of male Wistar strain rats in acute renal Failure.
The subject of the research were 30 male rats weighing 180-200 grams and 2-3 months old,
which were divided into 3 groups, namely the negative control group, the positive control
group and the treatment group. Each group consisted of 10 rats. The negative control group
was only given food and drink as usual. The positive control group and the treatment group
were induced with gentamicin 12 mg / intraperitonial for 7 days to increase urea and
creatinine serum levels. The treatment group was given steeping treatment of 0.65 grams of
boiled figs leaf in 100cc of given 3.6cc/orally for 7 days. One way ANOVA test was
conducted to analyse the study using SPSS version 24. The results found there are no
significant differences in urea serum levels between the treatment group and negative control
group (p = 0.252) but there were significant differences in the urea serum value between the
treatment group and positive control group (p <0.05). There was a significant difference in
the value of creatinine serum between the treatment group, the positive control group and the
negative control group (p <0.05). As Conclusions boiled figs leaf (Ficus Carica L) has an
effect on decreasing urea and creatinine serum levels in male wistar rats with acute renal
failure.