Investigating the Therapeutic Promise of Mimosa pudica for Diabetes: A Computational Perspective

Marvel Reuben Suwitono; Titin Sulastri

doi:10.35974/isc.v11i6.3652

Authors

Marvel Reuben Suwitono
Titin Sulastri

https://doi.org/10.35974/isc.v11i6.3652

Keywords:

Mimosa Pudica, Antidiabetic, Molecular Docking, Phytochemical

Abstract

The rising global incidence of diabetes mellitus underscores the urgent demand for innovative antidiabetic agents. This study investigates the therapeutic potential of Mimosa pudica L. (commonly known as the sensitive plant), recognized for its traditional medicinal uses, as a possible antidiabetic agent through an in-silico approach. Utilizing bioinformatics tools and databases, we conducted a comprehensive analysis of the phytochemical constituents of Mimosa pudica, concentrating on their molecular interactions and potential inhibitory effects on key diabetes-related enzymes, specifically 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1), Glutamine-Fructose-6-Phosphate Transaminase (GFAT), SIRT6, and Protein-Tyrosine Phosphatase 1B (PTP1B). Our findings reveal that certain bioactive compounds within Mimosa pudica exhibit strong binding affinity to these targets, suggesting potential inhibitory actions. This computational study provides compelling preliminary evidence for the antidiabetic efficacy of Mimosa pudica, positioning it as a candidate for further in-vitro and in-vivo investigations. The research highlights the significance of integrating computational methods in exploring plant-based therapeutics, which could revolutionize diabetes management strategies.

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