• Yunus Elon Faculty of Nursing Universitas Advent Indonsea
  • Jacqueline Polancos Adventist University of the Philippines

Kata Kunci:

Jeruk nipis, Kadar kolesterol darah



Pendahuluan: Tanpa penanganan kesehatan,klien hiperkolesterolemia akan mengalami komplikasi penyakit kardiovaskular dan bahkan kematian. Berolahraga dan pengobatan antihiperlipidemia dapat menurunkan resiko tersebut. Jeruk nipis (Citrus Aurantifolia) mengandung fitokimia yang memiliki efek menurunkan kolesterol darah. Tujuan: Untukmengetahui efek dari terapi jeruk nipis dan terapi jeruk nipis dibarengi olaraga terhadap penurunan kadar kolesterol total darah. Metode: Penelitian ini menggunakan quasi-experimental research design dengan membandingkan dua kelompok intervensi. Teknik sampling purposive digunakan untuk memilih 20 orang partisipan yang secara acak dibagi dalam 2 kelompok intervensi. Partisipan di kelompok pertama meminum jus jeruk nipis 1,5 cc/kgbb setiap pagi selama 7 hari. Sedangkan partisipan di kelompok kedua meminum jus jeruk nipis dengan dosis yang sama ditambah dengan olahraga 30 menit perhari selama 6 hari. Hasil: Rata-rata kadar kolesterol total responden pada kedua kelompok sebelum dan sesudah intervensi menunjukkan perubahan yang signifikan (p=<.05). Sedangkan skor pencapaian oleh kedua kelompok menunjukkan perbedaan yang tidak signifikan. Diskusi: Terapi jus jeruk nipis efektif  menurunkan kadar kolesterol darah karena kandungan fitokimianya yang aktif sebagai agen hipolipidemik.


Kata Kunci: Jeruk nipis, Kadar kolesterol darah


Introduction: Without health management, hypercholesterolemic clients would have cardiovascular diseases as complication, and even death. Exercise and anti-hyperlipidemic medication can decreased these health risks Lime (Citrus aurantifolia) possess phytochemicals that have reducing effects on blood cholesterol. Aim: To determine the effects of lime (Citrus aurantifolia) therapy and lime therapy with exercise on reducing blood total cholesterol level. Method: This study utilized a quasi-experimental design which compared two groups intervention. A purposive sampling technique was used to select 20 participants that randomly divided into 2 intervention groups.  Participants in the first group drinks 1,5 cc/kgbw  of lime juice every morning for 7 days. While participants in the second group drinks the same dosage of lime juice with 30 minutes exercise every day for 6 days. Results: The mean of total cholesterol level of participants in both groups before and after intervention reveal a significant changes (p=<.05). While the gain score of the two groups reveals no significant difference. Discussion: Lime juice therapy effective in reducing blood total cholesterol level for its active phytochemicals that acts as hypolipidemic agent.

Key words: Cholesterol level, Lime


Full printable version: PDF

Article Metrics


Data unduhan belum tersedia.


Aadahl, M., von-Huth S. L., Pisinger, C., Toft, U. N., Glumer, C., Borch-Johsen, K., Jorgensen, T. (2009). Five-year change in physical activity is associated with changes in cardiovascular disease risk factors. The Inter99study.Preventive Medicine 48 (4):326-331

Atsukwei, D., Eze, E. D., Adams, M. D., Adinoyi, S. S., & Ukpabi, C. N. (2014). Hypolipidemic effect of etanol leaf extract of moringa oleifera in experimentally induced hypercholesterolemic wistar rats. International of Nuutrition and food Science, 3 (4). 355-360

Boshtam, M., Asgary, S., Moshtaghian, J., Naderi, G., & Dinani, N. J. (2013). Impacts of fresh lime juice and peel on atherosclerosis progression in an animal model. ARYA Atheroscler, 9(6): 357–362.

Boshtam, M., Moshtaghian, J., Naderi, G., Asgary, S., & Nayeri, H. (2011). Antioxidant effects of Citrus aurantifolia (Christm) juice and peel extract on LDL oxidation. J Res Med Sci. 2011 Jul; 16(7), 951–955.

Centers for Disease Control and Prevention (2011, March). An estimated 1 in 10 U.S. adults report depression. Retrieved from

Daniels, R., & Nicoll, L. (2012).Contemporary Medical Surgical Nursing, 2nd ed. USA: Delmar Cengage Learning

Damle, M. (2014). Glycyrrhiza glabra (liquorice)- a potent medicinal herb. International of Herbal Medicine 2(2). 132-136

Departement Kesehatan RI (Dep. Kes. RI) Badan Penelitian Pengembangan Kesehatan, Riset Kesehatan Dasar (Riskesdas), Laporan Nasional (2013). Availableat

Dhaliya, S. A., Surya A. S., Dawn V. T., Carla, B., Kumar, A., & Sunil, C. (2013). A Review of hyperlipidemia and Medicinal Plants. Int. J. A. PS>BMS, Vol 2 (4). Oktober-Desember 2013.219-237

Eckel, R. H., Jakicic, J. M., Ard, J. D., de Jesus, J. M., Miller, N. H., Hubbard. V. S., Lee, I. M., ... et al. (2013). 2013 AHA/ACC Guideline on Lifestyle Management to Reduced Cardiovascular Risk. J Am Coll Cardiol, 63 (25-PA)

Griffin, R. M. (2011). Heart Disease: What are the Medical Costs? Available at

Griffin, R. M. (2014). High Cholesterol: What It Can Do to You. Available at management/features/high-cholesterol-risks-top-2-dangers

Guo, W., Kawano, H., Piao, L., Node, K., & Sato, T. (2011). Effects of aerobic exercise on lipid profiles and high molecular weight adiponectin in Japanese workers. International Medicine, 50 (5), 389-395. Retrieved from http://www.researchgate. net/publication/50271174_Effects_of_aerobic_exercise_on_lipid_profiles_and_high_molecular_weight_adiponectin_in_Japanese_workers

Hatma, R. D. (2011). Lipid Profiles among Diverse Ethnic Groups in Indonesia. Acta Med Indones-Indones J Intern Med, 43 (1), 4-11

Kelley, G. A., Kelley, K. S., & Franklin, B. (2006). Aerobic exercise and lipids and lipoproteins in men: a meta-analysis of randomized controlled trials. J Cardiopulm Rehabil.26 (3). 131-139

Kelly, R. B. (2010-May). Diet and exercise in the management of hyperlipidemia. American Family Physician. 81 (9); 1097-1102

Lee, K. H., Park, E., Lee, H.J., Kim, M. O., Cha, Y. J., Kim, J. M., Lee, H., & Shin. M. J. (2011). Effects of daily quercetin-rich supplementation on cardiometabolic risks in male smokers.Nutrition Research and Practice;5(1):28-33

Letizmann, M. F. Park, Y., Blair, A., Ballard-Barbash, R., Mouw, T., Hollenbeck, A. R., & Schatzkin, A. (2007).Physical activity recommendations and decreased rsik of mortality. Arch Intern Med, 167 (22):2453-2460

Lira, F. S., Yamashita, A. S., Uchida, M. C., Zanchi, N. E., Gualano, B., Martins Jr, E., Caperuto, E. C., & Seelaender, M. (2010) Low and moderate, rather than high intensity strength exercise induces benefit regarding plasma lipid profile. Diabetology & Metabolic Syndrome, 2:31

Moon, J., Lee, S. M., Do, H. J., Cho, Y., Chung, J. H., & Shin, M. J. (2012). Quercetin Up-regulates LDL Receptor Expression in HepG2 Cells. Phytotherapy Research. 26 (11); 1688-1694

National Cholesterol Education Program (2001).Detection, evaluation and treatment of high blood cholesterol in adults (adult treatment panel III). NIH Publication No. 01-3670. Washington, DC: U.S. Government Printing Office.

Nelson, R. H. (2013). Hyperlipidemia as a Risk Factor for Cardiovascular Disease.Prim Care. 2013 March ; 40(1): 195–211. doi:10.1016/j.pop.2012.11.003.

Norton, K. (2011). Phytochemicals: health benefits of saponins. Health Articles, September 17, 2011.

Ochani, P. C., & D’Mello, P. D. (2009). Antihyperlipidemic activity of Hibiscus S. Linn. Leaves and Calyses ectracts in rats. Indian journal of Experimental Biology. Vol 47, April 2009, 276-282

Oikeh, E. I., Omoregie1, E. S., Oviasogie, F. E., & Oriakhi, K. (2015).Phytochemical, antimicrobial, and antioxidant activities of different citrus juice concentrates.Food Science &Nutrition 4(1): 103–109. doi: 10.1002/fsn3.268

Oinam, N., Urooj, A., Phillips, P. P., & Niranjan, N. P. (2012). Effect of dietary lipids and drumstick leaves (Moringaoleifera) on lipid profile & antioxidant parameters in Rats. Food and Nutrition Science, 3:141-145

Okwu, D. E. (2008). Citrus fruits: A Rich Source of Phytochemicals and their Role in Human Health. Int. J. Chem. Sci.: 6(2), 2008, 451-471

Roshan, A., Verma, N K., Kumar, C. S., Chandra, V., Singh, D. P., & Panday, M. K. (2012). Phytochemical Constituent, Pharmakological Activities, and Medicinal Uses Through the Milinia of Glycyrrhiza Glabra Linn: A Review. International Research Journal of Pharmacy 3 (8). 45-55

Smeltzer, S. C., Bare, B. G., Hinkle, J. L., & Cheever, K.H. (2010). Brunner & Suddarth’s textbook of Medical Surgical Nursing, 12thed, vol 1. Philadelphia: Wolter Kluwer Health/Lippincott William & Wilkins

Tajoda, H. N., Kurian, J. C., & Bredenkamp, M. B. (2013).Reduction of cholesterol and triglycerides in volunteers using lemon and apple.International Journal of Humanities and Social. 3 (18); 60-64

Tappia, P. S., Xu, Y. J., & Dhalla, N. S. (2013). Reduction of Cholesterol and Other Cardiovascular Disease Risk Factors by Alternative Therapies.Clinical Lipidology.8 (3).345-359

WHO. (2015). Global Health Observatory (GHO) Data: Raised Cholesterol. Available at

WHO.(2014). Noncommunicable Diseases (NCD) Country Profiles. Available at




Cara Mengutip




Keperawatan Medikal Bedah