The Effectiveness Fig Leaves (FICUS CARICA L) Steeping Water Towards SGOT SGPT Serum on Male Wistar Rats in Critical Hepatitis Model

Yosi Julianti; Untung Sudharmono

doi:10.35974/isc.v7i1.2087

Authors

Yosi Julianti Universitas Advent Indonesia
Untung Sudharmono Universitas Advent Indonesia

https://doi.org/10.35974/isc.v7i1.2087

Keywords:

Paracetamol, SGOT, SGPT, Ficuss carica L.

Abstract

Critical Hepatitisis is the inflammation of the liver that is caused by viruses, alchol and drugs which are characterized by the increasing values of SGOT SGPT. The purpose of this study is to determine the effectiveness of fig leaves (Ficuss carica L) steeping water towards the decrease of SGOT SGPT serum on male wistar rats in critical hepatitis model. The object of this study is 30 male wistar rats with the age of 2-3 months and weight 180-200 grams and randomly divide into 3 groups, which are the negative group that is only by giving an usual food and drink, the positive group and the treatment groups are given paracetamol 120mg/ oral for 7 days. The treatment group is given 0.65 gram/ day of fig leaves steeping water for 7 days. One way ANOVA of SPSS version 24 is used to analyze this research. The result of the study shows that there is a significant difference in SGOT serum level between the treatment group, positive group and negative group (p<0,05). And there is a significant difference in SGPT level between the treatment group and the positive group (p<0,05). The conclusion of this study is tin leaves (Ficus carica L) steeping water has an effect towards the decrease of SGOT SGPT in male Wistar rats in critical hepatitis model.

Article Metrics

Downloads

Download data is not yet available.

Author Biography

Yosi Julianti, Universitas Advent Indonesia

Student Faculty of Nursing, Universitas Advent Indonesia

References

Aref, H. L., Mosbah, H., Louati, H. Said, & K., Selmi, B. (2011). Partial characterization of a novel amylase activity isolated from Tunisian Ficus carica latex. Pharmaceutical Biology. 49(11). 1158-66.

A haddin, (2014). Isolation and cytotoxicity of flavonidaun tin extract (ficus carica linn) . Bogor: IPB .

Azlinda M. A., (2019). Antibacterial activity test of methanol extract of fruit and fig leaf (ficus carica L) against pathogenic bacteria streptococcus pneumoniae. Journal of Pure and Applied Microbiology. 6(3), 1105-1110.

Berata, I. K., Winaya, I.B. O., Adi, A. A. A. M., Adnyana, I. B. W. (2011). General veterinary pathology. Denpasar: private pass.

Bhattacharya, D., Roy, S., Sribastav, S., Chanda, R., Paul, S., Chowdhury, G. Intravenous paracetamol infusion can prologue duration of spinal anesthesiabin patiens undergoing major gynecological surgeries. Int J Sci Nat. 2013(4910), 23-8 .

Budiyanto, D. (2016). Alert!! 2.9 Million More Indonesian Population Has Hepatiti s. Kompasiana, (September, 2014), pp.2-9. Available at: http://www.kompasiana.com/de-be/waspada-2-9-juta-more-puduk-indonesia-mengidhepatitis_54f5dcb6a333112b1f8b4754.

Diah K., Hidayat S., Wahyu D. K., (2014). Potential hepatoprotector propolis against liver of white rats (rattus norvegicus) induced by carbon tetrachloride. Available at: https://www.researchgate.net/publication/327305810_POTENSI_HEPATOPROTEK TOR_PROPOLIS_TERHADAP_HEPAR_TIKUS_PUTIH_Rattus_norvegicus_YAN G_DIINDUKSI_KARBON_TETRAKHLORIDA_Hepatoprotective_Potential_of_Pr opolis_toward_Hepar_Injury_Rats_Rattus_norvegicus_Indu.

Eva A., (2017). Uji Aktivitas Senyawa Antioksidan dari Ekstrak Daun Tiin (Ficus Carica Linn) Dengan Pelarut Air, Metanol dan Campuran Metanol-Air. Klorofil: Jurnal Ilmu Biologi dan Terapan. 1(1), 38-47.

Hadi S. J., Maribelle A. R., (2018). Effects of intravenous paracetamol on spinal anesthesia sensory regression with 0.5% hyperbaric bupivacaine. Saudi J Anaesth. 8(2), 202-208. doi: 10.4103/1658-354X.130719

Imantika C., Amallia N. S., Kusmiyati T. DK. (2016). Effect of Dewa Leaf Extract (Gynura Divaricata) on sgot and sgpt levels (experimental studies in female Sprague Dawley rats model of breast cancer). Kedokteran, Universitas Diponegoro, Semarang, Jawa Tengah, Indonesia.

Jeong, M. R., Kim, H. Y., Cha, J. D. (2009). Antimicrobial activity of methanol extract from Ficus carica leaves against oral bacteria. J Bacteriol Virol. 39 (2): 97-102.

Lee, W. M. (2003). Drug-induced hepatotoxity. Nutr Engl J Med 349: 74-85.

Lozano, R. (2013). Global and regional mortality from 235 causes of death for 20 age groups in 1990s 2010. A systematic analysis for the 2010 global burden of disease study. The lancet, 380 (9859), p. 2096. Available at: ejournal.almaata.ac.id/indec.php/INJD/article/download/272/247

Nahleh, Z., and Imad, A. T. (2003). Complementary and alternative medicine in breast cancer patients. Palliative and Supportive Care. 1(3), 267-273.

Nuha R. A., (2018). Effect of noni (morinda citrifolia L.) extract on the number of hepatocyte swelling of male white rats (hundred norvegicus strain wistar) induced by alcohol.

Oliveira, A. P., Silva, L. R., Andrade, P. B. (2010). Determination of low molecular weight volatiles in the carious ficus using HS-SPME and GC / FID. Food chemistry, 121 (4), 1289-1295.

Rahmani, A. H., Aldebasi, Y. H. (2017). Ficus carica and its constituents role in management of diseases. Asian J Pharm Clin Res. 10 (6), 49-53.

Sri Oktavia, Ifora, Suhatri, Marni Susanti. (2017). Test the hepatoprotector activity of green betel leaf extract against liver damage induced by paracetamol.

Good thing Sudharmono. (2014). Safety test of mindi leaf ethanol extract ( Melia azedarach L. ) in Wistar strain rats based on lethal andosis 50 and liver and kidney hispatology features.

Wasley, A., fiore, A., & bell, B. P. (2006). Hepatitis A in theera vacciation. Epidemiologic reviews, 28(1), 101-111.

WHO. (2017). Global hepatitis report, available at: http: //www.who.int/hepatitis/publications/global-hepatitis-report2017/en/.

Zhao, J. Q., Wen, Y. F., & Bhadauria, M. (2009). Protective effects of propolis on inorganic mercury induced oxidative stress in mice. Indian J Biol Exp, 47(4), 264-26.