Effectiveness of boiled Comfrey Leaf (Symphytum Officinale L) on Ureum Creatinine Serum in Male Wistar Strain of Acute Kidney Failure model.

  • Pelagia Sedyati Universitas Advent Indonesia
  • Untung Sudharmono Universitas Advent Indonesia
Keywords: Gentamicin, Ureum, Creatinine, Symphytum Officinale L.

Abstract

Acute kidney failure is a decrease in kidney that occurs only in a matter of hours even days which can be seen from decreased urine production and increased blood urea nitrogen and creatinine. This study aims to determine the effectiveness of boiled comfrey leaf (symphytum officinale L) on Ureum Creatinine Serum in Male Wistar Strain of Acute Kidney Failure model. This research used 30 male Wistar strain rats weighing 180-200 grams and aged 2-3 months that were divided into 3 groups, namely negative group (only given minerals), positive group (kidney damaged by gentamicin 0.3cc IP / day) and the treatment group (the kidneys were damaged with gentamicin 0.3cc IP / day and 2.8 g of boiled comfrey leaf in 150 cc of water and 2.7 cc were given orally for 7 days). Data were analyzed with SPSS version 24, one way ANOVA test was performed to compare the levels of ureum and creatinine. The results showed that there was a significant difference in the ureum of the treatment group and the positive group (p <0.05) but there was no significant difference in the ureum value between the treatment group and the negative group. There was a significant difference in creatinine values between the treatment group, positive group and negative group (p <0.05). As a Conclusion boiled comfrey leaf (symphytum officinale L) water has an effect on decreasing serum levels of ureum creatinine in male rats wistar strain of acute kidney failure model.
Article Metrics

Downloads

Download data is not yet available.

References

Sudharmono, U, (2014). Uji Keamanan ekstrak Etanol Daun Mindi (Melia Azedarach L.) Pada Tikus Galur Wistar Berdasarkan Dosis Letal 50 Serta Gambaran Histopatologi Hepar dan Ginjal.

Jangga dan Suriani. (2016). Effects Test Leaf Extract Kompri (Symphytum Officinale L.) On Lowering Blood Glucose Levels Mice (Mus Musculus). The National Journal Of Pharmacy

Norma, Latif, U. T.A., Usman, S. (2014). Efek Hepatotoksisitas Ekstrak Etanol Herbal Kompri (SymphytumofficinaleL.) Terhadap Hewan Uji Kelinci (Oryctolaguscuniculus) Dengan Parameter SGOT dan SGPT. 2(1), 11-15

Gonzalez, D.L.N., Perez, Y.V.T., Nunez, W.E.R. (2016). Determination of Polyphenols and Antioxidant Activity of Polar Extracts of Comfrey (Symphytum Officinale L).

Seigner, J., Samek, M. J., Plaza, A., , G.,Masullo, M., Piacente, S., Schichl, Y. M. H., Martin, R. D. (2019). A Symphytum officinale Root Extract Exerts Anti-inflammatory Properties by Affecting Two Distinct Steps of NF-κB Signaling. Department of Vascular Biology, Medical University of Vienna, Vienna, Austria

Kurdi, A. (2010). Komfrey (Symphytum officinale L). Cara mengolah dan manfaatnya bagi kesehatan. Tanaman Herbal Indonesia. hal. 154

Situmorang, H.E. (2015). Hubungan Dukungan Keluarga Dengan Kualitas Hidup Pasien Gagal Ginjal Kronis Yng Menjalani Terapi Hemodialisa Di RSUD DOK II Jayapura.

Davis CP. Creatinin blood test. 2015 jan 13 [cited 2015 oct 8]. Available from : http://www.medicinenet.com/creatini ne_blood_test/article.htm

Indrasari, Nur, Denita. (2015). Perbedaan Kadar Ureum Dan Kreatinin Pada Pasien Gagal Ginjal Kronik Berdasarkan Lama Menjalani Terapi Hemodialisa Di RS PKU Muhammadiyah Yogyakarta.

Hurst, M. (2016). Keperawatan Medikal Bedah. Vol.1. Penerbit Buku Kedokteran (EGC).

LeMone, P., Burke, K.M., Bauldoff, G. (2016). Keperawatan Medikal Bedah. Vol.3, Edisi 5.

Putra, T.A., Hafizh, M. (2018). Implementasi Metode Dempster Shafer pada Sistem Pakar Diagnosis Penyakit Ginjal Berbasis Web dengan Menggunakan PHP dan MySQL. 7(2).

Endriastuti, N. E., Wahyono, D., Sukarno, R. (2015). Evaluation of Gentamicin Doses for Treating Children with Severe Pneumonia. Journal of Management and Pharmacy Practice. 5(1)

Normasari, R., Dewi, R., & Rachmania, S. (2017). Study of Kidney Repair Mechanism of Cassava Leaf Extract on Gentamicin induced Nephrotoxicity. Journal of Agromedicine and Medical Sciences. 3(1)

Siahaan, G. S et al, (2016). Gambaran histopatologik ginjal tikus wistar (Rattus norvegicus) yang diinduksi gentamisin dan diberikan ubi jalar ungu (Ipomoea batatas L. Poir). Jurnal e-Biomedik (eBm), 4(1)

Abbas, K., Rizwani, G. H., Zahid, H., Qadir, M, i. Vol. 30, May 2017, pp. 881-890. Evaluation of nephroprotective activity of Musa paradisiaca L. in gentamicin-induced nephrotoxicity. Department of Pharmacognosy, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan

Rajak, Z. F. W., Loho, L., Lintong, P. (2016) Gambaran histopatologik ginjal wistar yang diberi ekstrak binahong pasca pemberian gentamisin. Jurnal e-Biomedik (eBm), 4(2)

Published
2019-12-18
How to Cite
Sedyati, P., & Sudharmono, U. (2019). Effectiveness of boiled Comfrey Leaf (Symphytum Officinale L) on Ureum Creatinine Serum in Male Wistar Strain of Acute Kidney Failure model. Abstract Proceedings International Scholars Conference, 7(1), 705-715. https://doi.org/10.35974/isc.v7i1.2075

Most read articles by the same author(s)

1 2 > >>